13K views · 174 reactions | Acute hepatic porphyria is caused by defects in heme biosynthesis enzymes; the accumulation of neurotoxic heme intermediates causes injury to the nervous system and other organs. Attacks typically warrant urgent medical attention, and options for preventing attacks are limited. New research findings are summarized in a short video. https://nej.md/2MrQOmI | The New England Journal of Medicine | Facebook