The Middle East has been transformed since 7 October, and almost two years on, the conflict in Gaza is at another inflection point.

Britain threatened Tuesday to take further action against Israel if it does not agree to end the war in Gaza, a day after two dozen mostly European countries condemned Israel’s restrictions on aid shipments into the territory and the killings of hundreds of Palestinians trying to reach food.

Nearly 30 nations issued a joint statement saying Israel's ongoing war with Hamas in Gaza has "reached new depths" and "must end now."

Israeli strikes in Gaza killed at least 21 people late Tuesday and early Wednesday. More than half of those killed were women and children, health authorities said. Desperation is mounting in the Palestinian territory of more than 2 million,

The aid agency says its buildings in the central part of the territory were attacked after the military targeted Deir al-Balah, which had largely been spared.

Israeli tanks on Monday rolled into a part of central Gaza that has not previously seen ground operations in the 21-month war, according to Israeli media, aid agencies and witnesses.

Israeli tanks pushed into southern and eastern districts of the Gazan city of Deir al-Balah for the first time, an area where Israeli sources said the military believes hostages may be held.

A six-week-old infant and three other children have died of starvation in Gaza in the past 24 hours, local health officials said, with malnutrition and starvation now killing Palestinians faster than at any point in the 21-month war.