The San Francisco 49ers and the Seattle Seahawks face off in Week 1 of the NFL regular season today. Here's where to watch and start time.

The injury-riddled San Francisco 49ers visit the Tampa Bay Buccaneers in a matchup of a pair of 4-1 teams leading their respective divisions in the NFC

The 49ers continue to be banged up for yet another week. Two of San Francisco's three quarterbacks on the roster, and their top two receivers are on the injury report again, and that doesn't account for tight end George Kittle, who's missed the last four games.

The San Francisco 49ers begin their quest to a Supe Bowl with the season-opener against the Seattle Seahawks today. Find out how to watch this NFL game for free.

The SportsLine Projection Model has revealed its San Francisco vs. Tampa Bay picks for the 2025 NFL Week 6 contest

The Tampa Bay Buccaneers' defense has defined strengths and weaknesses. They rank first in expected points allowed against the run and 27th in the same statistic against the pass. If the San Francisco 49ers want to beat the Buccaneers, they are going to need to expose this weakness.

The San Francisco 49ers will take on the Seattle Seahawks in Week 1 of the NFL season on Sunday at Lumen Field.

The Seahawks get set to travel to Jacksonville for a matchup vs. the 4-1 Jaguars in Week 6 at EverBank Stadium. The team will wear their all-white uniform set for the cross-country road trip. The Opposing View, An Insider's Look At The Seahawks' Week 6 Opponent, The Jacksonville Jaguars

The Seattle Seahawks and San Francisco 49ers face off in Week 1 of the NFL season today. Here's where to watch and start time.

The Chargers play at the Dolphins, the 49ers play at the Buccaneers and the Seahawks make the cross country flight to play at Jacksonville.