Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Actin filaments are dynamic protein-fibers in the cell built from single actin proteins. Many cellular functions, including cell movement, are regulated by constant filament assembly and disassembly.

Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics ...

Cell on the move. A dendritic cell (actin inside the cell is shown in blue) crawls through a collagen gel (magenta). Immune responses rely on the efficient movement of immune cells within the complex ...

Research has demonstrated that actin waves propagate via actin polymerization on the substrate-attached cell membrane at the wave’s front and disassembly at the back of the wave. 4 Proteins named Arp2 ...

The cytoskeleton is far more than a static scaffold—it’s a dynamic, adaptable network that shapes cells, moves cargo, and drives vital processes. From swirling cytoplasmic flows to microtubule ...