Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.

President Donald Trump on Friday urged Iran to quickly reach an agreement on curbing its nuclear program as Israel vowed to continue its bombardment of the country. Trumped framed the volatile moment in the Middle East as a possible "second chance” for Iran's leadership to avoid further destruction "before there is nothing left

The Israeli strikes killed top Iranian military leaders and nuclear scientists ahead of planned weekend negotiations aimed at addressing international concerns over Iran's uranium enrichment program.