Potent DNA-recombination method developed for large cargo delivery in gene therapy

Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying ...
pv magazine International

Longi builds 27.25%-efficient back-contact solar cells with high-resistivity wafers

High-resistivity silicon wafers offer superior efficiency potential but are highly sensitive to edge recombination and mechanical damage, limiting their commercial use compared to more robust standard ...
ascopubs.org

Deep Learning Artificial Intelligence Predicts Homologous Recombination Deficiency and Platinum Response From Histologic Slides

Menopausal Hormone Therapy and Ovarian and Endometrial Cancers: Long-Term Follow-Up of the Women's Health Initiative Randomized Trials Cancers with homologous recombination deficiency (HRD) can ...
Science Daily

Evolutionary advantage of genetic recombination in the genome measured for first time

Researchers have quantified one of the most important and hard-to-measure phenomena in molecular evolution: the effect of genetic recombination on a species' capacity of adaptation. UAB researchers ...
ascopubs.org

Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial

Eight hundred and six patients were randomly assigned (2:1). Tumors were analyzed using the Myriad MyChoice HRD Plus assay to assess non–BRCA HRRm and HRD status; HRD was based on a genomic ...
mskcc.org

Homologous Recombination and DNA repair

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...