Manual patch clamping requires considerable skill and experience due to the technically challenging setup requirements, and as such, only allows recording of a small sample of cells (approximately ...

Cells send electrical impulses throughout the body, but electrophysiologists struggled to tune into these signals until the patch clamp technique was developed. The year’s most impressive achievements ...

In neuroscience, combining patch-clamping with protein identification in the same cell is becoming increasingly important to define which subtype or developmental stage of a neuron or glial cell is ...

For decades, neuroscientists have struggled to learn the precise sequence of steps necessary to perform patch-clamp electrophysiology on neurons in a living brain. Now, engineers have dumped the ...

Flip-the-Tip Technology Uses Standard Glass Pipettes to Achieve Higher Throughput in Ion Channel Screening The pharmaceutical industry has widely recognized patch clamping as the “gold standard” to ...

(Nanowerk News) From its invention in the 1970s, the patch clamp technique is the gold standard in electrophysiology research and drug screening because it is the only tool enabling accurate ...

A group of researchers at MIT and Georgia Tech has built a robotic arm that can automate whole-cell patch clamping, a complicated technique that normally requires great manual dexterity and takes ...

Since its introduction by Bert Sakmann and Erwin Neher in 1978, patch-clamping techniques have become widely accessible with commercially available equipment. And while the science of patch clamping ...

To obtain electrophysiological recordings in brain slices, sophisticated and expensive pieces of equipment can be used. However, costly microscope equipment with infrared differential interference ...

An interview with Tim Strassmaier and James Constantin, Nanion Technologies, conducted at SfN 2018 by Alina Shrourou, BSc. Could you give our readers a bit of general background as to what ion ...