A newly discovered molecule disrupts cancer cells’ ability to repair DNA by triggering the breakdown of key proteins. Cancer ...

Loss of an enzyme necessary for a process called lipoylation disrupts the way cancer cells copy their DNA, increasing their ...

The cancer drugs called PARP inhibitors have a puzzling reputation: even though they are treatment mainstays for multiple forms of cancer, they can damage cancer-killing T cells and disrupt the ...

For cancers that harbor gene mutations that weaken DNA repair, poly-ADP ribose polymerase (PARP) is like a crutch. It ensures that these cancers can keep DNA repair going well to survive. But what if ...

PARP Inhibitors Clinical Trial Pipeline Accelerates as 25+ Pharma Companies Rigorously Develop Drugs for Market Entry | DelveInsight The PARP inhibitor clinical trial analysis report delivers ...

Learn more about a new experimental procedure that uses cancer cells’ DNA repair system against itself to make drug-resistant ...

Researchers at MD Anderson have identified RNase H2 as a key survival mechanism in triple-negative breast cancer, helping ...

A whole-genome sequencing approach shows early promise over current commercial methods for identifying more patients likely to benefit from PARP inhibitor cancer treatments, according to a study led ...

Researchers at AACR described the development of a classifier that identified a proportion of tumor samples with HRD that did not have BRCA1/2 mutations.

Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important ...