Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system. Archaeosine is a modified nucleoside found only in the tRNAs from archaea, the so-called third ...

This is a preview. Log in through your library . Abstract Combined vaccine formulations targeting not only hemagglutinin but also other influenza virus antigens could form the basis for a universal ...

Nucleoside analogues are modified forms of natural nucleosides that have become indispensable in both therapeutic and diagnostic applications. Their structural alterations enable them to interfere ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

BERLIN — To date, mRNA vaccines have had their largest global presence in combating the COVID-19 pandemic. Intensive research is underway on many other potential applications for this vaccine ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self ...

The public is invited to attend Nobel Prize winner Katalin Karikó’s free lecture at Scripps Institution of Oceanography on March 25 Hungarian-American biochemist and researcher Katalin Karikó has been ...

In adults with chronic hepatitis B infection receiving viral suppression therapy, coupling an investigational small interfering RNA therapy with an immunomodulator led to substantial declines in blood ...

Katalin Karikó, PhD, is professor at University of Szeged, Hungary, and adjunct professor of neurosurgery at the Perelman School of Medicine, University of Pennsylvania, where she worked for 24 years.