Pre-eclampsia is one of the most serious complications in pregnancy, affecting millions of women and newborns worldwide.

NFE2-related factor 2 (NRF2) is a transcription factor that integrates cellular stress signals and responds by directing various transcriptional programmes. NRF2 was a somewhat esoteric protein little ...

INrf2 tethering of the transcription factor Nrf2 in the cytosol prevents Nrf2 activation of antioxidant response element (ARE) mediated gene expression. This investigation was undertaken to determine ...

Researchers have discovered that the transcription factor NRF2 plays a major role in herpes infection and thus is an effective target for restricting viral infection. The herpes simplex virus (HSV) is ...

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance. Central to this ...

Sitryx Therapeutics Ltd. has identified itaconate compounds acting as nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; NFE2L2; NRF2) activators reported to be useful for the ...

LITTLE ROCK, Ark.--(BUSINESS WIRE)--Kuria Therapeutics, a pharmaceutical company developing novel ophthalmic and dermal therapeutics, is pleased to announce it has completed a pre-Investigational New ...

C4XD will receive milestone payments worth up to $16m ahead of the first clinical trial C4XD will receive milestone payments worth up to $16m ahead of the first clinical trial C4XD – a company focused ...

AstraZeneca has moved to strengthen its respiratory disease pipeline, wagering $400 million in biobucks for the global rights to a preclinical C4X Discovery NRF2 activator program with applications in ...