Despite the replacement of the monoamine hypothesis of depression with a more comprehensive understanding of multiple influencing factors in the pathology of depression, it is clear that elevating ...

Medically reviewed by Erika Prouty, PharmDMedically reviewed by Erika Prouty, PharmD Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressants that block the reuptake of both ...

In 2015, Harel Weinstein’s team used the Titan supercomputer at the US Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL) to produce the first end-to-end simulation of a sodium ion, ...

Many details have recently been worked out describing events in any brain exposed to the most common addictive drugs: heroin, morphine, barbiturates, tranquilizers, and alcohol (all depressants that ...

Researchers have identified the protein GLT-1 as the neurotransmitter glutamate transporter in the brain that is related to cortical spreading depression, a pathological condition that underlies ...

Sceletium tortuosum, a succulent indigenous to South Africa, has been used for centuries for its mood-altering properties, with traditional applications ranging from stress alleviation to mood ...

The first pharmacologic therapies for the treatment of depression were MAOIs introduced in the mid-1950s (Keller, 2003; Pacher & Kecskemeti, 2004). As mentioned previously, MAOIs inhibit monoamine ...