Most cancer treatments are based on using the maximum tolerated dose of a drug to kill as many cancer cells as possible. While this approach has led to patients achieving good responses to therapy, ...

Chimeric antigen receptor T-cell therapy, or CAR T, is a relatively new type of therapy approved to treat several types of aggressive B cell leukemias and lymphomas. Many patients have strong ...

Researchers use mathematical modeling to help explain why CAR T cells work in some patients and not in others. Chimeric antigen receptor T-cell therapy, or CAR T, is a relatively new type of therapy ...

Researchers demonstrate how mathematical modeling combined with dynamic biomarkers can be used to characterize metastatic disease and identify appropriate therapeutic approaches to improve patient ...

Repetitive transcranial magnetic stimulation (rTMS) and other targeted, noninvasive neuromodulation approaches offer promise for treating neuropsychiatric conditions. These techniques work by ...

Cell and gene therapies are exciting new modalities that have the potential to treat, and even cure, a range of diseases that may not be possible with small molecules or monoclonal antibodies. However ...

The spectrum of metabolic dysfunction-associated steatotic liver disease (MASLD) ranges from simple lipid accumulation in the human liver, to steatohepatitis with inflammation, fibrosis, cirrhosis, ...

Chimeric antigen receptor (CAR) T-cell therapy shows significant potential in treating various human cancers. Unfortunately, researchers have faced difficulty in adapting this therapy to target solid ...

Objectives: To describe the types of clinically actionable medication-related problems (MRPs) identified and the types of resolving recommendations issued by pharmacists using an advanced clinical ...