About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...
In a recent study published in the journal Nature, researchers from the United States of America developed the synthetic intramembrane proteolysis receptor (SNIPR) architecture to activate engineered ...
Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...
The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant glycoproteins accounting for 90 percent of the total mass. Finding a ...
Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a ...
Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma The following represents disclosure information provided by ...
Capturing Unicorns: Targeting Cancers With TP53 Mutations, RAS Alterations Beyond G12C, and MTAP Loss—No Target Is Out of the Realm of Possibility Bispecific antibodies (bsAbs) have emerged as a novel ...
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