Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in ...

The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic ...

Consistent with findings from experimental research in nonhuman primates exposed to early-life stress, children exposed to maltreatment are at high risk of detrimental physical health conditions, such ...

The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) recommended marketing authorization for metreleptin (Myalepta, Aegerion Pharmaceuticals BV) for the treatment of ...

Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...

AstraZeneca today announced the US Food and Drug Administration (FDA) approved orphan drug MYALEPT™ (metreleptin for injection), which is indicated as an adjunct to diet as replacement therapy for the ...

Typically, when PD is diagnosed, half of the dopaminergic axons and neurons within the substantia nigra pars compacta are already lost. Thus, there is an urgent need to identify early PD markers. The ...

Please provide your email address to receive an email when new articles are posted on . Increasing leptin levels are independently associated with decreasing testosterone and could be a cause for ...