Researchers at Israel's Weizmann Institute of Science report that lymphocytes rolling on high endothelial venules stop abruptly in response to chemokines presented by endothelial cells. 1 Their ...

Integrin α-4/β-7 - also known as Lymphocyte Peyer’s patch adhesion molecule-1 (LPAM-1) - is an integrin heterodimer composed of covalently linked α-4 and β-7 subunits. Expressed on the surface of ...

The immune system plays a dual role in inflammation and cancer development. Immune system effector cells quickly identify and destroy malignant cells, but immune system-mediated inflammation regulates ...

A team of researchers from the Universities of Amsterdam and Zurich together with the Swiss company Allocyte Pharmaceuticals have for the first time been able to discover allosteric sites in a type of ...

Cells are the fundamental unit of life. The average human body contains around 30 trillion cells with varying functions and potentials. Communication between cells is central to the body’s ability to ...

This is a preview. Log in through your library . Abstract Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly ...

Extracellular vesicles are tiny spheres that cells release to send molecules or messages to other cells, often as a means of seeding cancer elsewhere in the body. In a new study, researchers found ...

Recent advances in the management of inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, have shown that inhibiting the interaction between the α4β7 integrin and the ...

The immune system plays a dual role in inflammation and cancer development. Immune system effector cells rapidly recognize and kill malignant cells; meanwhile, immune system-mediated inflammation ...