The immune system’s capacity to distinguish self from non-self is in large part mediated by immunoglobulins, with IgG playing a pivotal role in both protective and pathological responses.

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, ...

A Japanese research team has uncovered how sugar chains (glycans) modifications dynamically regulate the structure and function of human immunoglobulin G (IgG) antibodies. By integrating nuclear ...

Daniel R. Lucey, Stephen A. McGuire, Mario Clerici, Kevin Hall, Jean Benton, Clifford A. Butzin, William W. Ward, Gene Shearer, R. Neal Boswell and Craig W. Hendrix β₂-microglobulin levels were ...

IdeS IgG protease shows promise for Myasthenia Gravis, Immune Thrombocytopenia, and dozens of other IgG-driven autoimmune diseases. The wild type enzyme elicits potent anti-drug antibodies (ADA) that ...

This is a preview. Log in through your library . Abstract Idiotypy has been studied in antibodies against a protein antigen: hen ovalbumin. Various fractions of antisera to hen ovalbumin have been ...

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019, and ...