The accumulation of neurofibrillary tangles is the common thread among all tauopathies, yet each amasses fibrils with a distinct fold at their core. What forces goad tau into twisting into these ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 15 (April 12, 2022), pp. 1-10 (10 pages) In neurodegenerative diseases including Alzheimer’s and ...

Researchers have developed a potential new peptide-based drug delivery system by repurposing fibrils that contribute to Alzheimer’s disease pathogenesis. Researchers at the University of North ...

Researchers have identified a possible 'Achilles' heel' in the frustration of amyloid beta peptides as they dock to the fibrils that form plaques in patients with Alzheimer's disease. Progress on ...

The spike protein of SARS-CoV-2, the virus that causes COVID-19, has been the focus of a lot of research these past two years. It’s what the virus uses to invade host cells and it has been the target ...

Researchers outline how they used a chemical probe to light up interlocking peptides. Their technique will help scientists differentiate synthetic peptides from toxic types found in Alzheimer's ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a primarily respiratory virus. It is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. In severe or ...

After studying 140,000 versions of the Aβ42 peptide, scientists identified some of the earliest molecular interactions that drive the formation of harmful amyloid protein aggregates found in Alzheimer ...

A team led by LMU chemist Oliver Trapp reports in Nature Communications. The formation of peptide bonds – the chemical bond between amino acids – in protein synthesis is one of the most important ...