A defanged form of CRISPR, which doesn’t slice or nick DNA, but rather alters the epigenome — the layers of chemical coding that sit on top of DNA and control the activity of genes — has aced its ...

Sizable investments. High-profile appearances at industry events. Unique development platforms. These elements would augur well for companies of any kind—and companies hoping to bring epigenome ...

A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, ...

In a recent study posted to the preprint server Research Square* while under review for publication in Epigenetics & Chromatin, researchers develop and characterize a highly specific EpiEditing system ...

DURHAM, N.C. & SEATTLE--(BUSINESS WIRE)--Last week, at the 26th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), leading epigenetic editing company Tune Therapeutics showcased ...

Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription ...

Prof David R. Liu, Professor at Harvard University, the Broad Institute, and HHMI was interviewed by the Sheeky Science Show. In the interview, they discussed how to make precise genome editing safe & ...

A one-off injection might be able to permanently reduce the risk of heart disease by reversibly switching off a gene in the liver, according to a study in mice. The findings suggest that the approach ...

More than 15 million people worldwide struggle with alcohol use disorder, a chronic relapsing condition that can have severe consequences on a person’s physical, emotional, and mental wellbeing.

Genes are regulated by complex interactions involving transcription factors, DNA regulatory regions, and epigenetic modifications which alter chromatin structure. Modifications to chromatin regulate ...

Creative depiction of the epigenetic editing toolkit: each building represents the epigenetic state of a single gene (dark windows are silenced genes, lit up windows are active genes). The crane ...