Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

Objective: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, ...

THE role of bacterial endotoxins in the pathogenesis of infections due to endotoxin-containing bacteria is not clear. It is commonly assumed that endotoxin is a major factor in determining toxicity ...

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...

Endotoxins can trigger severe inflammatory responses, which can result in conditions such as organ dysfunction, blood hypercoagulation, and systemic inflammatory response syndrome. These risks make ...

Heat-labile exotoxin of Pseudomonas aeruginosa has been purified and concentrated. Studies in mice have shown that the toxin affects protein synthesis in the liver within 3 hr of administration, ...

Jai Prakash (left) is a Professor in the Department of Advanced Organ Bioengineering and Therapeutics at the University of Twente (Enschede, Netherlands), where he works with Postdoc Marcel Heinrich ...

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

The presence of harmful bacteria in parenteral drugs or implantable devices can cause inflammatory responses such as fever and, in some cases, may even be fatal. As a result, robust bacterial ...

What are the benefits of microfluidic automation? Microfluidic automation is the most straightforward available form of automation for endotoxin testing on the market today. It streamlines endotoxin ...