The endoplasmic reticulum (ER) is the gateway to the secretory pathway in all eukaryotic cells. Its products subsequently pass through the Golgi apparatus on the way to the cell surface (true ...
Cells have extensive sets of intracellular membranes, which together compose the endomembrane system. The endomembrane system was first discovered in the late 1800s when scientist Camillo Golgi ...
Mutations in the presynaptic protein α-synuclein, or even just overexpression, can cause Parkinson disease (PD) by killing off midbrain dopaminergic neurons. Despite evidence that the deadly effects ...
Uso1p, a Saccharomyces cerevisiae protein required for ER to Golgi transport, is homologous to the mammalian intra-Golgi transport factor p115. We have used genetic and biochemical approaches to ...
A study entitled "IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport", now published in the open access journal "Cellular and Molecular Life Sciences", provides new ...
The secretory pathway in eukaryotic cells is crucial for maintaining cellular function and physiological activities, as it ...
Scientists at Whitehead Institute, in collaboration with colleagues at several research centers, have identified a key biological pathway that, when obstructed, causes Parkinson's symptoms. Even more ...
In the United States, prostate cancer (PCa) is the second-leading cause of cancer death in men. Multiple observations indicate the link between prostate carcinogenesis, stress of endoplasmic reticulum ...
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