A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human ...

Figure 1: p53-family-based cell-fate decisions. Figure 2: p53 family functions in myogenic differentiation and in rhabdomyosarcoma. Even in the modern era of cancer genomics, the classic ...

ATP-dependent chromatin-remodelling enzymes use the energy of ATP hydrolysis to alter histone–DNA contacts and to facilitate changes in chromatin structure. These are important steps in the regulation ...

Adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace ...

The human genome contains over 4.5 million sequences of DNA called “transposable elements”, these virus-like entities that “jump” around and help regulate gene expression. They do this by binding ...

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins ...

Revise differentiation of algebraic and trigonometric expressions, which can be used for calculating rates of change, stationary points and their nature, or the gradient and equation of a tangent to a ...

Proceedings of the American Mathematical Society, Vol. 36, No. 2 (Dec., 1972), pp. 485-490 (6 pages) This paper is concerned with differentiation of interval functions appearing in interval analysis.

For an inner function θ on the upper half-plane ℂ+, we look at the star-invariant subspace ${\mathrm{K}}_{0}^{\mathrm{p}}:={\mathrm{H}}^{\mathrm{p}}\cap \mathrm ...