During the early phases of oncogenic clonal expansion, precancerous cells experience replication stress that threatens both genomic integrity and viability. How replication stress tolerance (RST) ...
Faithful duplication of the genome demands precise coordination between DNA replication and RNA transcription, two processes that share and compete for the same DNA template. When replication forks ...
A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...
Scientists have identified a previously unrecognized layer of the human genome. It's built not from DNA's usual building blocks, but from small fragments of RNA embedded directly inside it. Georgia ...
Researchers have engineered Detectrons, toehold-switch biosensors coupled to retron reverse transcription, that convert ...
Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore injured tissue. The discovery came from studying tiny molecular messages ...
Scientists may have found a clue to one of the biggest mysteries surrounding the origin of life: how fragile RNA molecules could gather and survive before cells existed. New research shows that RNA is ...
As antibiotic-resistant infections rise and are projected to cause up to 10 million deaths per year by 2050, scientists are looking to bacteriophages, viruses that infect bacteria, as an alternative.
Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth—a key process in the origin of life. Scientists ...
Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...
We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...
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