The Arizona Cardinals, losers of three straight games, are on the road in Week 6. They face the 4-1 Indianapolis Colts Sunday, kicking off from Lucas Oil Stadium at 1 pm. ET (10 a.m. Arizona time). The Colts are big favorites in the game.

The Indianapolis Colts take the AFC South lead by extending the Arizona Cardinals' losing streak: Stats, scores.

The Indianapolis Colts are preparing for their fourth home defense when they match up this afternoon with the Arizona Cardinals. This gridiron face-off features Colts head coach Shane Steichen against Jonathan Gannon.

The Arizona Cardinals are in a foul mood as they take a break from the NFL grind, mired in a frustrating five-game losing streak that has raised some uncomfortable questions about the direction of the franchise.

Arizona Cardinals quarterback Jacoby Brissett will start in place of Kyler Murray for Sunday's game against the Indianapolis Colts.

One ESPN analyst thinks Indianapolis Colts running back Jonathan Taylor will slow down against the Arizona Cardinals.

Arizona Cardinals tight end Travis Vokolek was placed on a stretcher and taken off the field on a golf cart after injuring his neck on a kickoff return against the Indianapolis Colts.

But the Cardinals (2-3) are probably a better test for the Colts (4-1) than they look on paper.

Quarterback Daniel Jones led the Colts to a 31-27 victory over the Cardinals on Sunday. Andy Lyons / INDIANAPOLIS — They found out, at first, through whispers. “Did you hear what happened to A.R.? What about Mooney?

Daniel Jones threw two touchdown passes and Jonathan Taylor ran 1 yard for the go-ahead score with 4:32 left, giving the Indianapolis Colts a 31-27 victory over the Arizona Cardinals.

Sunday's Week 7 NFL schedule provides bettors an opportunity to take advantage of the latest FanDuel promo code, which offers new users $300 in bonus bets if their first wager of $5 or more wins. The Indianapolis Colts (5-1) and Los Angeles Chargers (4-2) suit up at 4:05 p.