Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of them doesn’t function. Likely not, according to the findings of a new ...

Thoracic Radiotherapy Improves the Survival in Patients With EGFR-Mutated Oligo-Organ Metastatic Non–Small Cell Lung Cancer Treated With Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitors: A ...

Sisters often share certain genetic traits, such as hair color and facial features. But for three sisters from Minnesota, they discovered a much deeper connection—a shared genetic mutation known to ...

A study led by Harvard Medical School researchers shed new light on how even a single defective copy of the tumor-suppressor BRCA1 gene can increase patients’ risk of developing breast cancer.

Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at ...

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

Carriers of the BRCA1 cancer gene had a significantly increased risk of breast cancer if they used hormonal contraception (HC), pooled cohort data showed. Breast cancer risk increased by 29% in BRCA1 ...

Deescalated nab-paclitaxel plus carboplatin showed higher efficacy than nab-paclitaxel plus gemcitabine in early-stage TNBC patients. BRCA1/2 mutation carriers exhibited a more pronounced pathologic ...

In women with BRCA1 mutations, hormonal contraceptives were associated with a significantly higher risk for breast cancer in a dose-response relationship, researchers reported in an observational ...

The full name of the BRCA1 gene is “breast cancer 1, early onset,” and it codes for a tumor suppressor protein. Tumor suppressor proteins help repair DNA that has become damaged in order to ensure the ...